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Contraindicated. CYP3A4 is responsible for the development and elimination of cariprazine's Energetic metabolites. The impact of CYP3A4 inducers on cariprazine exposure hasn't been evaluated as well as the net outcome is unclear.pentobarbital will lessen the extent or effect of glecaprevir/pibrentasvir by affecting hepatic/intestinal enzyme CYP3A4